乌普萨拉大学、洛桑联邦理工学院最新岗位制博士项目分享

本期为大家推荐哥本哈根大学、查尔姆斯理工大学最新25/26岗位制博士项目信息。

哥本哈根大学

PhD fellowship in Biophysical neuropharmacology at Department of Neuroscience

UCPH | Laboratory for Membrane Protein Dynamics

APPLICATION DEADLINE：31-08-2025

We are offering a PhD fellowship in biophysical neuropharmacology commencing 1 November 2025 or as soon as possible hereafter.

Our group and researchAt the Laboratory for Membrane Protein Dynamics we explore the neurotransmitter transporters, in particular the ones responsible for the termination of the serotonergic and dopaminergic signals. These transporters are the main target for antidepressants and cocaine/amphetamines, respectively. We reveal their multifaceted nature, acting as molecular motors which harvest the energy to drive substrate transport from ion gradients. These remarkable entities exhibit properties from enzymes (transport kinetics), receptors (inhibitor binding) and channels (current properties). Our research is grounded in fundamental molecular pharmacology but has for the last decade adopted a suite of cutting-edge biophysical techniques.

We utilize a blend of structural biology (single particle cryo-EM), protein design (non-canonical amino acids), fluorescence (environmental sensitive dyes, FRET), ligand binding and transport assays (radioligand). Our work delves into unravelling the intricacies of protein dynamics governing transport protein function. The impact of substrates, ions, and inhibitors on this dynamic interplay forms the crux of our investigation.

We purify the transporters, incorporating them into structural (Nielsen et al. 2024 Nature) and functional (Nygaard et al. 2024 Nat Commun) studies using platforms like proteoliposomes (Schmidt et al. 2022 Nat Commun) or nanodiscs (Pugh et al. 2022 Cells).

Project description

The current project concerns the site-specific insertion of fluorescent non-canonical amino acids (ncAAs) into the human dopamine transporter (hDAT). To do this, we use genetic code expansion employing the amber stop codon for the insertion. Several suitable locations within the hDAT proteins must be explored. When successful, the hDAT mutant(s) will be expressed and purified from HEKexpi cells. The fluorescent readout from the ncAA can then report on the intrinsic conformational changes that will be induced in hDAT upon the binding of ions, inhibitors or during dopamine transport. These investigations have never been done before on hDAT.

Principal supervisor is Professor Claus J. Løland, Department of Neuroscience, cllo@sund.ku.dk, Direct Phone: 28756407.

Start: 1 November 2025

Duration: 3 years as a PhD student

Job descriptionYour key tasks as a PhD student at SUND are:

Carry through an independent research project under supervision
Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points
Participating in active research environments including a stay at another research team
Obtain experience with teaching or other types of dissemination related to your PhD project
Teach and disseminate your knowledge
Write a PhD thesis on the grounds of your project

Key criteria for the assessment of applicantsApplicants must have qualifications corresponding to a master’s degree related to the subject area of the project e.g. molecular biomedicine, human biology, neuroscience, biochemistry or related educations. Please note that your master’s degree must be equivalent to a Danish master’s degree (two years, 120 ECTS).

In connection with the appointment to the post, special attention will be applied to applicants having some of the following professional and personal qualifications:

Knowledge or experience with molecular biology (PCR, cloning)
Knowledge or experience with purification and functional characterization of membrane proteins, preferentially eucaryotic proteins.
Knowledge or experience with size exclusion chromatography (Cytiva/ÄKTA purifier)
Experience with radioligand binding assays.
Experience with expression and insertion of proteins into nano discs or proteoliposomes
Excellent communication skills, both written and oral

Other important criteria are:

The grade point average achieved
Professional qualifications relevant to the PhD project
Previous publications
Relevant work experience
Other professional activities
Curious and self-driven mind-set with a strong interest in experimental biology
Excellent language skills, both spoken and in writing

All highly motivated and ambitious candidates, regardless of their personal background and status, are encouraged to apply.

Application procedureYour application must be submitted electronically by clicking ‘Apply now’ below. The application must include the following documents in PDF format:

Motivated letter of application (max. one page)
CV incl. education, experience, language skills and other skills relevant for the position
Certified copy of original Master of Science diploma and transcript of records in the original language, including an authorized English translation if issued in other language than English or Danish. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor is accepted. As a prerequisite for a PhD fellowship employment, your master’s degree must be equivalent to a Danish master’s degree. We encourage you to read more in the assessment database: https://ufm.dk/en/education/recognition-and-transparency/find-assessments/assessment-database. Please note that we might ask you to obtain an assessment of your education performed by the Ministry of Higher Education and Science
Publication list (if possible)

Application deadline: August 31, 23.59 pm CET.

查尔姆斯理工大学

PhD student position in Characterisation of the Micromechanics of Quick Clays

Chalmers University of Technology | Department of Architecture and Civil Engineering

APPLICATION DEADLINE: 2025-08-15

Project overview

The aim is to unravel the mechanisms, and time scales involved at particle scale, for the formation and failure of quick clays. A novel combination of miniaturised thermal-hydro-mechanical experiments and particle level modelling will be pursued to unravel the unique mechanisms that make quick clays so hazardous and at the same time so special. The originality of the experiments is in the combination of X-ray based scattering and imaging methods to monitor the changes at the particle scale during testing.

Research environment

Geotechnics research at the Department of Architecture and Civil Engineering focuses on the characterisation and modelling of complex geomaterials, particularly natural clays. Our work bridges fundamental understanding with advanced modelling and testing capabilities, applied to real-world engineering challenges.

We are internationally recognised for our expertise in experimental testing and numerical modelling of natural clays at both laboratory and field scale. We are active members of the ALERT Geomaterials network and other international committees. Our diverse and international team of over 15 full-time researchers offers a stimulating and supportive environment to learn and grow.

Your profile

Required qualifications:

Undergraduate degree in Engineering, Physics or Mathematics with strong emphasis on Image Analysis and/or Geomechanics
Fluency in spoken and written English
Willingness to learn Swedish, as necessary for providing teaching support at undergraduate level
Genuine interest in investigating the fundamental response of quick clays using X-ray based experimental methods and fundamental modelling
Experience in programming

Merits:

Understanding of the mechanics of colloid systems
Experience with performing laboratory experiments
Ability to work with large data sets (> 500 GB)
Numerical modelling

Main responsibilities

Independent research and research training (80% of time)
Support for education and activities within the research area and department (20% of time)
Potential for international collaborations and secondments
Opportunities for PhD, pedagogical and language courses both nationally and internationally (e.g. Nordic Five Tech and ALERT Geomaterials)

Contract terms

The position is a four-year appointment, with the possibility of extension up to five years through teaching (maximum 20%)

What we offer

Fully funded PhD position from the start
Starting salary of 34,550 SEK/month (valid from 25 May 2025)

How to applyThe application should be written in English be attached as PDF-files, as below. Maximum size for each file is 40 MB. Please note that the system does not support Zip files.

CV: (Please name the document: CV, Family name)

CV
Other, for example previous employments or leadership qualifications and positions of trust.

Personal letter: (Please name the document as: Personal letter, Family name)1-3 pages where you:

Introduce yourself
Describe your previous experience of relevance for the position (e.g. education, thesis work and, if applicable, any other research activities)
Describe your future goals and future research focus